A well written, compassionate and informative book on drugs that are lacking in any. The main title, pihkal, is an acronym that stands for phenethylamines i have known and loved the book is arranged into two parts, the first part. This book is an invaluable resource for researchers, physicians, chemists, and law enforcement. Mescaline was first synthesized in 1919 by ernst spath from 3,4. The main title is an acronym that stands for phenethylamines i have known and loved the book is arranged into two parts. Purchasing the book also gets you a far more complete crossindex into the chemicals described in the second half.
Extract the resulting mescaline base into methylene chloride three times, each with equal volumes of solvent. Its a hefty tome, half chemistry and half autobiography the latter part being half written by his wife anne. The second is more of a chemical reference, detailing in a more scientific method the creation and experiences of each pihkal s. Im sure all you know the hard that can be reach out with the precise word to show your idea of a feeling, vision, or effect. An improved synthesis of mescaline from gallic acid. A chemical love story phenylethylamines i have known and loved, and its continuation, tihkal which stands for tryptamines i have known and loved, where he makes a detailed explanation and analysis of how he discovered, synthesized and personally. A legal in the usa online source of trichocereus pachanoi san pedro seeds. Mescaline is a psychoactive derived from the peyote cactus and others from the trichcereus family namely the san pedro. Pihkal phenylethylamines i have known and loved, subtitled a chemical love story, is the autobiography of alexander and ann shulgin. It is offered in the catalogs of all the major chemical supply houses for a few pennies per gram.
Extensive crossreferencing tables for rapid location of key information. Thiomescaline tm is a pair of lesserknown psychedelic drugs with the molecular formula c11h17no2s. A chemical love story, info about mescaline synthesis. Mescaline is biosynthesized from tyrosine which, in turn, is derived from phenylalanine by the enzyme phenylalanine hydroxylase.
Shulgan explored the known phenthalamines, then produced hundreds of completely new chemicals and analogs in his quest to explore a class of chemicals that ranges from mescaline to mdma ecstacy. Each effect has mix, two controls over effect changes and a low pass filter or damping. Lsd, mescaline and more books about psychedelic drug use, from lsd and the tryptamines to mescaline and its phenethylamine derivatives. Alexander shulgin and ann shulgin, published in 1991. It is a very strong base with a fishy smell, and rapidly forms a solid carbonate salt upon exposure to the air. Shulgan explored the known phenthalamines, then produced hundreds. Tyrosine can either undergo a decarboxylation via tyrosine decarboxylase to generate tyramine and subsequently undergo an oxidation at carbon 3 by a monophenol hydroxylase or first be hydroxylated by tyrosine hydroxylase to form ldopa and decarboxylated by dopa decarboxylase. The first half of pihkal is an excellent commentary on the shulgins personal experiences with phenethylamines.
Each chemical contains information on its synthesis, dosage, effects, and commentary. Mescaline is one of the oldest psychedelics known to man. The mixture was held at reflux for an additional 5 min, at which point everything had gone into solution. Allylescaline was first synthesized by otakar leminger in 1972. A chemical love story the book is arranged in two parts. Incorrect book the list contains an incorrect book please specify the title of the book. The second half of the book consists of descriptions of the chemical synthesis. The second part is even more interesting it is a summery of years and. The second part contains detailed synthesis instructions for over 200 psychedelic compounds most of which.
I was also given the opportunity to introduce to mescaline a wellknown and respected yoga teacher karta singh, one of the first students of yogi bhajan who brought kundalini yoga to the west in 1968. Around 1960 he took the psychedelic drug mescaline, and became interested in. Mescaline, isolated by arthur heffter in 1897, is the active component of psychedelic cacti such as peyote lophophora williamsii and wachuma echinopsis pachanoi, also known as san pedro. Reflections on sacred drugs, mysticism and science. Mescaline, naturally occurring alkaloid, the active principle contained in the flowering head of the peyote cactus of mexico and the southwestern united states, that has been used as a drug to induce hallucination. This book is now widely considered to be one of the single most important pieces of. Download pihkal a chemical love story pdf epub ebook. A solution of 20 g 3,4,5trimethoxybenzaldehyde, 40 ml nitromethane, and 20 ml cyclohexylamine in 200 ml of acetic acid was heated on the steam bath for 1 h. The first half of pihkal is an excellent commentary on the shulgins personal experiences.
Book two describes a catalog of phenethylamines, with details about synthesis and reported activity. It is the major active component of the small dumpling cactus known as peyote. In 1991, alexander and ann shulgin first published their book called phenethylamines i have known and loved, a collection of years worth of work documenting in detail the synthesis and subjective effects of over 250 phenethylamines, including mescaline. Pihkal phenethylamines i have known and loved is a unique book written by renowned psychopharmacologist alexander shulgin and his wife ann shulgin. Shulgins choices of synthesis procedures in the second half of the book are. Pihkal translated to spanish, the last details petition. In experiments mescaline requires 2 to 3 hours for onset of action. In 1994, two years after the publication of pihkal, the dea raided the shulgin lab. Synthesis of mescaline from 2,6dimethoxyphenol using the mannich reaction.
The second part is even more interesting it is a summery of years and years of psychadelic research on phenthalamines. The first tells the story of the authors lives and their exposure to pihkal s. Syringaldehyde from 5bromovanillin by estercatalyzed methanolysis. This book gives details of their research and investigations into the use of psychedelic drugs for the study of the human mind, and is also a love story. The book seems to be largely distributed under the acronym, pikhal. A chemical love story by alexander shulgin, ann shulgin. Similar to the other classic psychedelics, mescaline is a 5ht 2a2c agonist and one of the most selectively. Novel, unifying mechanism for mescaline in the central. This compound has been made industrially by a number of routes, the motant being the reduction of benzyl cyanide and the decarboxylation of phenylanaline. Dr ecstasy, the man with the most claim to have actually discovered the drug.
Conversion of mescaline sulfate to mescaline hydrochloride is accomplished by first dissolving the sulfate in water. This is the first volume of north atlantic books updated paperback edition of dale. See the erowid mescaline dosage page for a more complete discussion of the forms of. Alexander shulgin and ann shulgin about psychedelic phenethylamines. The first use of mescaline dates back several centuries, when native american indians harvested it from the peyote cactus to use in religious ceremonies. The book is widely regarded as pioneering in the field, and is a respected work on the subject. In lophophora williamsii, dopamine converts into mescaline in a biosynthetic pathway involving momethylation and aromatic hydroxylation tyrosine and phenylalanine serve as the metabolic precursors to synthesis of mescaline. You can read about it in the book meetings with sergey baranov. Without much personal practice in chemical synthesis, i had to tiptoe and flyswat. It is highly recommended and well worth purchasing the book. To date, pihkal has sold more than 41,000 copies, a figure nearly unheardof for a selfpublished book.
In vivo studies on the metabolism of mescaline have shown that a large part of the mescaline combines with liver protein26 and varying amounts are excreted unchanged or as the oxidatively deaminated 3,4,5trimethoxyphenyacetic acid. Dom was popularised following the outlawing of lsd in the us. The reaction mixture was then diluted slowly and with good stirring, with 400 ml h2o, which allowed the formation of a heavy yellow crystalline mass. With the external heating removed, there was added 3. Swims cook book also covers more fiddly things such as growing large dmt crystals, separating dmt from 5meodmt, purifying sodium carbonate etc so that even an experienced person will likely find some techniques and ideas here to further develop their alchemical expertise. It was originally synthesized because someone got tired of spending half their. This impossible to categorize book is ostensibly the story of alexander shulgin, a. Tyrosine and phenylalanine serve as the metabolic precursors to synthesis of mescaline. An alternate synthesis was effective, using an excess of nitromethane as solvent as well as reagent, if the amount of ammonium acetate catalysis was kept small.
The first part is a fictionalized autobiography of the couple. If you are seriously interested in the chemistry contained. The 12 most important drugs shulgin designed, synthesised and. The first part is a personal story of exploration by the renowned chemist alexander shulgan. The subject of the work is psychoactive phenethylamine chemical derivatives, notably those that act as psychedelics andor empathogenentactogens.
Alexander shulgin was a chemist who invented lots of new psychedelic drugs. This html version of tihkal was created by bo lawler with the help of erowid. Alexander shulgin was the godfather of ecstasy, playing an instrumental. Im the head of the group that has translated pihkal and its beginning little by little with tihkal. Synthesis passes through any of 4 selectable custom dsp effects reverb which is huge and near infinite, notated tight delay, pitch shifter delay and palindrome reverse delay. Alexander sasha shulgin was an american chemist author of the famous book pihkal.
Using a strong base naoh or koh, adjust the ph of the solution to around 10. The mdma ecstasy synthesis published in pihkal remains one of the most. Mescaline is the primary psychoactive compound in the peyote cactus. Sacrifice your fears for your vision by frederic swiercz. A solution of 20 g 3,4,5trimethoxybenzaldehyde, 40 ml. Alexander shulgin and ann shulgin which was published in 1991. The second book is an index of 179 phenethylamines, which includes formula, synthesis, dosage, duration, qualitative comments and some extra commentary. Each chemical contains information on its synthesis, dosage, effects, and. It introduced shulgins work to a whole new audience and turned him into an. Here is a solid ab tek on cacti for any who are interested, as well as a good method to obtain snow white crystals every time. Although swim came up with this tek on his own, there were contributing influences by houses resin extraction, dgs titration, and various postings. The main title is an acronym that stands for phenethylamines i have known and loved the book consists of two parts.